Reconstruction of Wnt/calcium signaling pathway in C. elegans Wnt/kalsiyum sinyal yol i̇zinin C. elegans' ta oluşturulmasi
2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009, Balcova, Izmir, Türkiye, 20 - 22 Mayıs 2009, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Doi Numarası: 10.1109/biyomut.2009.5130319
- Basıldığı Şehir: Balcova, Izmir
- Basıldığı Ülke: Türkiye
- Boğaziçi Üniversitesi Adresli: Evet
Özet
Wnt signaling pathways play roles in many developmental processes such as, cell proliferation, differentiation, migration, and regulation of cell polarity. Disorders in Wnt/β-catenin signaling pathway members are known to cause many different cancer types. On the other hand, it has been reported that Wnt/Calcium signaling pathway can inhibit Wnt/β-catenin pathway, therefore it can act as tumor suppressor. In the present work we only report the homologs of the three main proteins of the Human Wnt/Calcium signaling pathway. Furthermore, nematode homologs found are investigated for the ultimate goal of using C. elegans as a model organism in future experimental studies on Wnt/Ca +2 signaling. ©2009 IEEE.