Vision transformer supported Kolmogorov-Arnold networks for survival prediction in lung cancer


Gökplnar M., Almalioglu Y., KOÇYİĞİT M. T., Kahveci T., Demir D., Başak K., ...Daha Fazla

16th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, ACM-BCB 2025, Pennsylvania, Amerika Birleşik Devletleri, 12 - 15 Ekim 2025, (Tam Metin Bildiri) identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Doi Numarası: 10.1145/3765612.3767200
  • Basıldığı Şehir: Pennsylvania
  • Basıldığı Ülke: Amerika Birleşik Devletleri
  • Boğaziçi Üniversitesi Adresli: Evet

Özet

Lung cancer is one of the most common and deadly cancers worldwide. Accurate survival prediction is critical for guiding treatment, yet existing deep learning approaches often struggle with capturing the complexity of histological and tabular features and fusing them effectively. We address these challenges by introducing a novel Kolmogorov-Arnold Network for tabular and fusion tasks, combined with advanced vision models for histology image processing. Experiments show that our method achieves superior survival prediction accuracy compared to unimodal predictors. Furthermore, it provides explainable predictions, as 10 of the top 20 genes identified as most influential are known to play roles in cancer survival and progression.